Endocrine Abstracts

With the increasing use of thyroid ultrasound (US), the recognition of thyroid nodules in a large proportion of apparently healthy subjects has become common. Moreover, some autopsy series have shown that papillary cancer measuring 10 mm or less, the so-called papillary thyroid microcarcinoma (PTMC), is a very frequent incidental finding. Because PTMC is being increasingly discovered, it is important to ascertain whether PTMC may exhibit heterogenous clinical and pathological ...

Hepatocytes are both insulin sensitive and the primary site for synthesis of SHBG. Thus, it is possible that a condition of hepatic insulin resistance may impair hepatic synthesis of SHBG. In this study, we assessed SHBG circulating levels after 30 days of a very low-calorie ketogenic diet (VLCKD) based on high-biological value protein preparations diet (ISOMED) and natural food in a cohort of insulin-resistant obese male subjects. Moreover, we investigated the effects of expo...

Low levels of testosterone and SHBG levels are often present in subjects with overweight and obesity; functional hypogonadism further alters the metabolic balance and may drag subjects in a sort of vicious cycle, reducing exercise and energy expenditure. The very low-calorie ketogenic diet (VLCKD) has been reported to rapidly reduce body weight, glycaemia and insulinemia, but its effects on total testosterone (TT) and SHBG levels are less clear. We thus aimed to evaluate the r...